Application of Membrane Separation Technology in Biopharmaceuticals
After the inorganic ceramic membrane clarifies the fermentation broth, it is equipped with ion exchange and organic nanofiltration membrane concentration to form an integrated process system.
Inorganic ceramic membranes have become the preferred separation technology for the bio-fermentation industry due to their unique chemical resistance, high temperature resistance, high separation accuracy and other performances .Can be widely used in the removal of organic acids (such as citric acid, lactic acid, itaconic acid, etc.), antibiotics (such as penicillin, erythromycin, etc.), vitamins (such as vitamin B2, vitamin B12, etc.), nitrogen acid and other fermentation broth Mycelium, macromolecular protein, yeast bacterial wall fragments, cell fibers, etc.
The ceramic membrane separation technology is completely superior to the traditional filtration methods such as plate and frame, rotating drum, centrifugation and diatomaceous earth etc.
Main feature:
● High temperature, high pressure and chemical corrosion resistant, long continuous working time, easy and efficient cleaning and regeneration;
● Through the dialysis cycle, the product yield is high, which is 5% -15% higher than the traditional filtration method;
● High separation accuracy and high transmittance of filtrate, reducing the difficulty of subsequent treatment;
● No additional additives are needed, the concentrated retentate (bacterial protein, etc.) can be used for feed recovery;
● Wide applicability, can handle almost any strong acid-base oxidizing chemical solution, resistant to strong polar solvents;
● High concentration factor, reduced dialysis water usage, significantly reduced wastewater discharge and COD, and promoted cleaner production;
● Good abrasion resistance, there are a variety of membrane channels to choose from, which can meet the processing requirements of various viscosity and solid content liquids;
● Long service life, low equipment investment and operating costs;
● Automatic control, both semi-automatic and manual control systems, simple and reliable operation, greatly reducing labor intensity.
Process flow:
Vitamin C membrane process flow
Fermentation liquid ceramic membrane filtration process
For biopharmaceuticals, ceramic membranes can meet the requirements of low temperature, sterility, and anti-pollution in the separation and purification process of their products, and have advantages that other separation equipment cannot match. As an important high-efficiency energy-saving separation equipment, ceramic membrane technology will be more and more widely used in biopharmaceuticals.
